ARG30295
VEGF ELISA Antibody Duo
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG56584 | anti-VEGF antibody [4B2-8] | Mouse mAb | Hu | ELISA, Neut, WB | 100 μg |
| ARG56586 | anti-VEGF antibody (Biotin) | Rabbit pAb | Hu | ELISA, WB | 25 μg |
Overview
| Product Description | Related news: The role of HDGF in tumor angiogenesis |
|---|---|
| Target Name | VEGF |
| Alternate Names | VEGF ELISA antibody; Vascular endothelial growth factor ELISA antibody; VEGF antibody; VEGF antibody (Biotin) |
Properties
| Storage Instruction | Store antibodies at 4°C or -20°C. Please refer to the each product datasheet for detail temperatures of the antibodies. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | VEGFA |
|---|---|
| Gene Full Name | Vascular endothelial growth factor (VEGF) ELISA Antibody Duo |
| Background | This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] |
| Function | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. [UniProt] |
