ARG54802

anti-ACE2 antibody

anti-ACE2 antibody for Western blot and Human

Cell Biology and Cellular Response antibody

Overview

Product Description Mouse Monoclonal antibody recognizes ACE2
Tested Reactivity Hu
Tested Application WB
Host Mouse
Clonality Monoclonal
Clone 881CT16.4.4
Isotype IgM, kappa
Target Name ACE2
Immunogen Purified His-tagged ACE2 protein.
Conjugation Un-conjugated
Alternate Names Angiotensin-converting enzyme homolog; ACEH; Angiotensin-converting enzyme 2; Metalloprotease MPROT15; ACE-related carboxypeptidase; EC 3.4.17.23

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control MCF7
Observed Size ~ 105 kDa

Properties

Form Liquid
Purification Purification by euglobulin precipitation.
Buffer PBS and 0.09% (W/V) Sodium azide
Preservative 0.09% (W/V) Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 59272 Human ACE2

Swiss-port # Q9BYF1 Human Angiotensin-converting enzyme 2

Gene Symbol ACE2
Gene Full Name angiotensin I converting enzyme 2
Background The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Function Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. [UniProt]
Cellular Localization Processed angiotensin-converting enzyme 2: Secreted
Highlight Related products:
ACE2 antibodies; ACE2 ELISA Kits; ACE2 recombinant proteins; Anti-Mouse IgM secondary antibodies;
Related news:
HMGB1, a biomarker and therapeutic target in COVID-19
ACE2, receptor of 2019-nCoV
Research Area Cell Biology and Cellular Response antibody
Calculated MW 92 kDa
PTM N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.