ARG70507
Human CD279 / PD-1 recombinant protein (His-tagged)
Human CD279 / PD-1 recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Human CD279 / PD-1 recombinant protein. |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD279 / PD-1 |
| Species | Human |
| A.A. Sequence | Met1 - Gln167 |
| Expression System | CHO |
| Protein Full Name | Programmed cell death protein 1 |
| Alternate Names | PDCD1; Programmed Cell Death 1; PD1; CD279; HSLE1; PD-1; Systemic Lupus Erythematosus Susceptibility 2; Programmed Cell Death Protein 1; Protein PD-1; SLEB2; HPD-1; Programmed Cell Death 1 Protein; CD279 Antigen; HPD-L |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | PDCD1 |
|---|---|
| Gene Full Name | Programmed Cell Death 1 |
| Background | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] |
| Function | The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. [Uniprot] |
