ARG70559
Mouse CD16 recombinant protein (His-tagged)
Mouse CD16 recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Mouse CD16 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD16 |
| A.A. Sequence | Leu32 - Thr215 |
| Expression System | CHO |
| Alternate Names | FCGR3A; Fc Gamma Receptor IIIa; FcgammaRIIIa; FcGRIIIA; CD16a; FCGR3; CD16; FCG3; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a); Fc Fragment Of IgG Receptor IIIa; IgG Fc Receptor III-A; IgG Fc Receptor III-2; Fc-Gamma RIII-Alpha; CD16a Antigen; CD16-II; IGFR3; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A/III-B Recombinant; Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment; Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16); Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B; Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16); Immunoglobulin G Fc Receptor III; Fc-Gamma Receptor III-2 (CD 16); Neutrophil-Specific Antigen NA; Fc-Gamma Receptor IIIb (CD16); Fc Gamma Receptor III-A; Fc-Gamma RIIIa; Fc-Gamma RIII; FcgammaRIIIA; FCGRIII; FCRIIIA; FcRIIIa; FCR-10; FCRIII; FcRIII; FcR-10; IMD20; CD16A |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | FCGR3A |
|---|---|
| Gene Full Name | Fc Gamma Receptor IIIa |
| Background | This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] |
| Function | Mediates enhanced ADCC in response to afucosylated IgGs. [Uniprot] |
