ARG70592
Mouse CD357 / GITR recombinant protein (His-tagged, C-ter)
Mouse CD357 / GITR recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged (C-ter) Mouse CD357 / GITR recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD357 / GITR |
| Species | Mouse |
| A.A. Sequence | Ser22 - Gln150 |
| Expression System | CHO |
| Alternate Names | TNFRSF18; TNF Receptor Superfamily Member 18; Tumor necrosis factor receptor superfamily member 18; GITR; Glucocorticoid-induced TNFR-related protein; CD357 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | TNFRSF18 |
|---|---|
| Gene Full Name | TNF Receptor Superfamily Member 18 |
| Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Cellular Localization | Cell membrane; Membrane; Secreted. [UniProt] |
| PTM | Disulfide bond; Glycoprotein. [UniProt] |
