ARG62352
anti-ACVR2A antibody [149/1]
anti-ACVR2A antibody [149/1] for Immunoprecipitation,Western blot and Human
Developmental Biology antibody; Metabolism antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [149/1] recognizes ACVR2A |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 149/1 |
| Isotype | IgG1 |
| Target Name | ACVR2A |
| Antigen Species | Human |
| Immunogen | Recombinant human type-2 activin receptor tyrosine kinase domain. |
| Epitope | Tyrosine kinase domain |
| Conjugation | Un-conjugated |
| Alternate Names | Activin receptor type IIA; ACTRIIA; ACTRII; ACVR2; EC 2.7.11.30; Activin receptor type-2A; ACTR-IIA |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | LS174T cells. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified Antibody |
| Buffer | 1X PBS and 0.1% Sodium azide |
| Preservative | 0.1% Sodium azide |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ACVR2A |
| Gene Full Name | activin A receptor, type IIA |
| Background | This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013] |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. [UniProt] |
| Research Area | Developmental Biology antibody; Metabolism antibody; Signaling Transduction antibody |
| Calculated MW | 58 kDa |
Clone References
Activin-A binds to a heterotrimeric receptor complex on the vascular endothelial cell surface. Evidence for a type 3 activin receptor.
Monoclonal antibodies that recognize the type-2 activin receptor, ACTR2.
