Overview

Product Description	Rabbit Polyclonal antibody recognizes AGTRAP
Tested Reactivity	Hu, Ms, Rat
Tested Application	ICC/IF, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	AGTRAP
Antigen Species	Human
Immunogen	Recombinant Protein of Human AGTRAP.
Conjugation	Un-conjugated
Alternate Names	ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein

Application Instructions

Application Suggestion	Tested Application Dilution ICC/IF 1:50 - 1:200 WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	BxPC-3

Properties

Form	Liquid
Purification	Affinity purification with immunogen.
Buffer	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 11610 Mouse AGTRAP GeneID: 298646 Rat AGTRAP GeneID: 57085 Human AGTRAP Swiss-port # Q642A2 Rat Type-1 angiotensin II receptor-associated protein Swiss-port # Q6RW13 Human Type-1 angiotensin II receptor-associated protein Swiss-port # Q9WVK0 Mouse Type-1 angiotensin II receptor-associated protein More
Gene Symbol	AGTRAP
Gene Full Name	angiotensin II receptor-associated protein
Background	This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Function	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. [UniProt]
Calculated MW	17 kDa

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