ARG45241
anti-ARL13B antibody
anti-ARL13B antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Polyclonal antibody recognizes ARL13B |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ARL13B |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human ARL13B. |
| Conjugation | Un-conjugated |
| Alternate Names | ARL13B; ARF Like GTPase 13B; ADP Ribosylation Factor Like GTPase 13B; ARL2L1; JBTS8; ADP-Ribosylation Factor-Like Protein 13B; ADP-Ribosylation Factor-Like 2-Like 1; ARL2-Like Protein 1; DKFZp761H079; ADP-Ribosylation Factor-Like Protein 2-Like 1; ADP-Ribosylation Factor Like GTPase 13B; ADP-Ribosylation Factor-Like 13B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 55 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q3SXY8 Human ADP-ribosylation factor-like protein 13B Swiss-port # Q640N2 Mouse ADP-ribosylation factor-like protein 13B |
|---|---|
| Gene Symbol | ARL13B |
| Gene Full Name | ARF Like GTPase 13B |
| Background | This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
| Function | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze fit; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis. [UniProt] |
| Cellular Localization | Cell membrane ; Cell projection ; Cilium ; Cytoplasm ; Cytoskeleton ; Membrane. [UniProt] |
| Calculated MW | 49 kDa |
| PTM | Isopeptide bond ; Lipoprotein ; Palmitate ; Ubl conjugation. [UniProt] |
