ARG45145
anti-BCAR3 antibody
anti-BCAR3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BCAR3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Target Name | BCAR3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to C-terminal region of human BCAR3. |
| Conjugation | Un-conjugated |
| Alternate Names | BCAR3; Breast cancer anti-estrogen resistance protein 3; Breast cancer anti-estrogen resistance protein 3; Novel SH2-containing protein 2; SH2 domain-containing protein 3B; BCAR3; NSP2; SH2D3B; UNQ271/PRO308; AND-34; MIG7; BCAR3, NSP Family Adaptor Protein; Migration Inducting Gene-7; DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3); Breast Cancer Antiestrogen Resistance 3 Protein; Epididymis Secretory Sperm Binding Protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 93 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O75815 Human Breast cancer anti-estrogen resistance protein 3 Swiss-port # Q9QZK2 Mouse Breast cancer anti-estrogen resistance protein 3 |
|---|---|
| Gene Symbol | BCAR3 |
| Gene Full Name | Breast cancer anti-estrogen resistance protein 3 |
| Background | Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| Function | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. [UniProt] |
| Cellular Localization | Cytoplasm; Cell junction, focal adhesion; Secreted. [UniProt] |
| Calculated MW | 93 kDa |
| PTM | Acetylation; Methylation; Phosphoprotein. [UniProt] |
