ARG22228
anti-CACNB2 antibody [S8B-1]
anti-CACNB2 antibody [S8B-1] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S8B-1] recognizes CACNB2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Specificity | Detects ~78 kDa. No cross reactivity against Cavβ1, Cavβ3, Cavβ4. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S8B-1 |
| Isotype | IgG1 |
| Target Name | CACNB2 |
| Antigen Species | Rat |
| Immunogen | Synthetic peptide around aa. 189-205 of Rat CACNB2 |
| Conjugation | Un-conjugated |
| Alternate Names | Lambert-Eaton myasthenic syndrome antigen B; CACNLB2; Voltage-dependent L-type calcium channel subunit beta-2; Calcium channel voltage-dependent subunit beta 2; CAVB2; CAB2; MYSB |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Cacnb2 |
| Gene Full Name | calcium channel, voltage-dependent, beta 2 subunit |
| Background | This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013] |
| Function | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. [UniProt] |
| Cellular Localization | Cell membrane, Sarcolemma |
| Calculated MW | 74 kDa |
| PTM | Regulated through phosphorylation at Thr-554 by CaMK2D. |
Images (1) Click the Picture to Zoom In
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ARG22228 anti-CACNB2 antibody [S8B-1] WB image
Western blot: Human cell line lysates stained with ARG22228 anti-CACNB2 antibody [S8B-1] at 1:1000 dilution.
