ARG42434
anti-CD172b / SIRPB1 antibody [B4B6]
anti-CD172b / SIRPB1 antibody [B4B6] for Flow cytometry and Human
Overview
| Product Description | Mouse Monoclonal antibody [B4B6] recognizes CD172b / SIRPB1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody B4B6 recognizes an extracellular epitope of CD172b, an approximately 50 kDa transmembrane glycoprotein expressed on myeloid cells. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B4B6 |
| Isotype | IgG1 |
| Target Name | CD172b / SIRPB1 |
| Antigen Species | Human |
| Immunogen | NIH/3T3 cells transfected with Human CD172b. |
| Conjugation | Un-conjugated |
| Alternate Names | CD antigen CD172b; CD172b; CD172 antigen-like family member B; SIRP-BETA-1; SIRP-beta-1; Signal-regulatory protein beta-1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SIRPB1 |
| Gene Full Name | signal-regulatory protein beta 1 |
| Background | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| Function | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985). [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 43 kDa |
| PTM | N-glycosylated. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG42434 anti-CD172b / SIRPB1 antibody [B4B6] FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG42434 anti-CD172b / SIRPB1 antibody [B4B6], followed by APC-conjugated Goat anti-Mouse antibody.
