Overview

Product Description	Rabbit Polyclonal antibody recognizes CD2
Tested Reactivity	Ms, Rat
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	CD2
Antigen Species	Mouse
Immunogen	Synthetic peptide corresponding to aa. 224-242 of Mouse CD2. (FIFCICKRRKRNRRRKDEE)
Conjugation	Un-conjugated
Alternate Names	T-cell surface antigen T11/Leu-5; LFA-3 receptor; T-cell surface antigen CD2; SRBC; Erythrocyte receptor; CD antigen CD2; T11; Rosette receptor; LFA-2

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size	~ 50 kDa

Properties

Form	Liquid
Purification	Affinity purification with immunogen.
Buffer	0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA.
Preservative	0.05% Thimerosal and 0.05% Sodium azide
Stabilizer	5% BSA
Concentration	0.5 mg/ml
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 12481 Mouse CD2 GeneID: 497761 Rat CD2 Swiss-port # P08920 Mouse T-cell surface antigen CD2 Swiss-port # P08921 Rat T-cell surface antigen CD2
Gene Symbol	CD2
Gene Full Name	CD2 molecule
Background	CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
Function	CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. [UniProt]
Cellular Localization	Cell membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW	39 kDa

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