ARG66227
anti-CD273 / PD-L2 antibody [24F.10C12]
anti-CD273 / PD-L2 antibody [24F.10C12] for CyTOF®-candidate,Flow cytometry,Functional study,IHC-Frozen sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [24F.10C12] recognizes CD273 / PD-L2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | CyTOF®-candidate, FACS, FuncSt, IHC-Fr |
| Specificity | This antibody recognizes CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin's lymphoma cells and primary mediastinal B cell lymphoma (PMBL). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 24F.10C12 |
| Isotype | IgG2a |
| Target Name | CD273 / PD-L2 |
| Antigen Species | Human |
| Immunogen | Human CD273. |
| Conjugation | Un-conjugated |
| Alternate Names | B7DC; bA574F11.2; PDL2; CD antigen CD273; PD-L2; Programmed cell death 1 ligand 2; CD273; Btdc; PDCD1L2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; PD-1 ligand 2; PDCD1 ligand 2 |
Application Instructions
| Application Suggestion |
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| Application Note | Functional study: anti-CD273 / PD-L2 antibody [24F.10C12] can be used to block PD-1 binding to its ligand. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PDCD1LG2 |
| Gene Full Name | programmed cell death 1 ligand 2 |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). [UniProt] |
| Highlight | Related products: PD-L2 antibodies; PD-L2 ELISA Kits; Anti-Mouse IgG secondary antibodies; Related news: CyTOF-candidate Antibodies The best solution for PD-1/PD-L1 research |
| Calculated MW | 31 kDa |
