ARG44613
anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE)
anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE) for Flow cytometry and Human,Primates
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody recognizes CD49e / Integrin alpha 5 |
|---|---|
| Tested Reactivity | Hu, NHuPrm |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SAM1 |
| Isotype | IgG2b |
| Target Name | CD49e / Integrin alpha 5 |
| Antigen Species | Human |
| Immunogen | U937 cells |
| Conjugation | PE |
| Alternate Names | ITGA5; Integrin Subunit Alpha 5; CD49e; FNRA; Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide); Fibronectin Receptor, Alpha Polypeptide; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-5; Integrin Alpha-F; VLA-5; Very Late Activation Protein 5, Alpha Subunit ; Fibronectin Receptor, Alpha Subunit; ITGA5/SLC9B1 Fusion; CD49e Antigen; VLA5A |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified antibody is conjugated with R-phycoerythrin (PE), and free fluorochrome are removed by size-exclusion chromatography. |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ITGA5 |
| Gene Full Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
| Background | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] |
| Function | Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt] |
| Cellular Localization | Cell junction, Cell membrane, Membrane. [UniProt] |
| Calculated MW | 115 kDa |
| PTM | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt] |
Images (1) Click the Picture to Zoom In
-
ARG44613 anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG44613 anti-CD49e / Integrin alpha 5 antibody [SAM1] (PE) at 10 μl/ 100 μl dilution.
