ARG40022
anti-CDK5RAP3 antibody
anti-CDK5RAP3 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CDK5RAP3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CDK5RAP3 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-300 of Human CDK5RAP3 (NP_788276.1). |
| Conjugation | Un-conjugated |
| Alternate Names | IC53; PP1553; C53; LZAP; Protein HSF-27; OK/SW-cl.114; CDK5 regulatory subunit-associated protein 3; MST016; LXXLL/leucine-zipper-containing ARF-binding protein; CDK5 activator-binding protein C53; HSF-27 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | U-87 MG | ||||
| Observed Size | 65 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q96JB5 Human CDK5 regulatory subunit-associated protein 3 |
|---|---|
| Gene Symbol | CDK5RAP3 |
| Gene Full Name | CDK5 regulatory subunit associated protein 3 |
| Background | This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013] |
| Function | Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity). [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes and associates with microtubules. [UniProt] |
| Calculated MW | 57 kDa |
| PTM | May be phosphorylated by CDK5. Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1. May be ufmylated. Cleaved by caspases early during apoptosis, the resulting peptides may play a role in rupture of the nuclear envelope. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG40022 anti-CDK5RAP3 antibody WB image
Western blot: 25 µg of U-87 MG cell lysate stained with ARG40022 anti-CDK5RAP3 antibody at 1:1000 dilution.
