ARG54738
anti-CDKN1C / p57 Kip2 antibody [522CT9.5.1]
anti-CDKN1C / p57 Kip2 antibody [522CT9.5.1] for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes CDKN1C / p57 Kip2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 522CT9.5.1 |
| Isotype | IgM |
| Target Name | CDKN1C / p57 Kip2 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 34-64 of Human CDKN1C (NP_000067.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Cyclin-dependent kinase inhibitor p57; BWS; WBS; BWCR; KIP2; Cyclin-dependent kinase inhibitor 1C; p57; p57Kip2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HL-60 |
Properties
| Purification | Affinity purification with immunogen. |
|---|---|
| Buffer | Crude ascites and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P49918 Human Cyclin-dependent kinase inhibitor 1C |
|---|---|
| Gene Symbol | CDKN1C |
| Gene Full Name | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| Background | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| Function | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProt] |
| Cellular Localization | Nucleus. |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody |
| Calculated MW | 32 kDa |
Images (1) Click the Picture to Zoom In
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ARG54738 anti-CDKN1C / p57 Kip2 antibody WB image
Western blot: 35 µg of HL-60 cell lysate stained with ARG54738 anti-CDKN1C / p57 Kip2 antibody.
