Overview

Product Description	Rabbit Polyclonal antibody recognizes CERK
Tested Reactivity	Hu, Ms
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	CERK
Antigen Species	Human
Immunogen	KLH-conjugated synthetic peptide corresponding to aa. 487-516 (C-terminus) of Human CERK.
Conjugation	Un-conjugated
Alternate Names	dA59H18.3; dA59H18.2; hCERK; Ceramide kinase; Lipid kinase 4; LK4; Acylsphingosine kinase; EC 2.7.1.138

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:1000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	Mouse heart

Properties

Form	Liquid
Purification	Purification with Protein G.
Buffer	PBS and 0.09% (W/V) Sodium azide
Preservative	0.09% (W/V) Sodium azide
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 223753 Mouse CERK GeneID: 64781 Human CERK Swiss-port # Q8K4Q7 Mouse Ceramide kinase Swiss-port # Q8TCT0 Human Ceramide kinase
Gene Symbol	CERK
Gene Full Name	ceramide kinase
Background	CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Function	Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. [UniProt]
Cellular Localization	Cytoplasm. Membrane; Peripheral membrane protein
Research Area	Cell Biology and Cellular Response antibody; Cell Death antibody
Calculated MW	60 kDa

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