ARG40244
anti-CHAC1 antibody
anti-CHAC1 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CHAC1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CHAC1 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide within the N-terminal region of Human CHAC1. |
| Conjugation | Un-conjugated |
| Alternate Names | Botch; Gamma-GCG 1; Glutathione-specific gamma-glutamylcyclotransferase 1; Cation transport regulator-like protein 1; EC 2.3.2.-; Blocks Notch protein |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | ~ 24 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 30% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CHAC1 |
| Gene Full Name | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
| Function | Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. [UniProt] |
| Cellular Localization | Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network. [UniProt] |
| Calculated MW | 24 kDa |
Images (1) Click the Picture to Zoom In
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ARG40244 anti-CHAC1 antibody WB image
Western blot: U2OS, HeLa, Raw264.7 and PC12 whole cell lysates stained with ARG40244 anti-CHAC1 antibody.
