ARG58387
anti-CLCN5 antibody
anti-CLCN5 antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CLCN5 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CLCN5 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 637-816 of Human CLCN5 (NP_001121370.1). |
| Conjugation | Un-conjugated |
| Alternate Names | XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2; H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | SW480 | ||||
| Observed Size | 100 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CLCN5 |
| Gene Full Name | chloride channel, voltage-sensitive 5 |
| Background | This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013] |
| Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. [UniProt] |
| Cellular Localization | Golgi apparatus membrane, Multi-pass membrane protein, Endosome membrane, Cell membrane. [UniProt] |
| Calculated MW | 83 kDa |
| PTM | Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG58387 anti-CLCN5 antibody WB image
Western blot: 25 µg of SW480 cell lysate stained with ARG58387 anti-CLCN5 antibody at 1:1000 dilution.
