ARG45964
anti-CLEC12A antibody [50C1]
anti-CLEC12A antibody [50C1] for Flow cytometry and Human
Overview
| Product Description | Mouse Monoclonal antibody [50C1] recognizes CLEC12A |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 50C1 |
| Isotype | IgG2a |
| Target Name | CLEC12A |
| Antigen Species | Human |
| Immunogen | 293T cells expressing human CLEC12A |
| Alternate Names | CLEC12A; C-type lectin domain family 12, member A; Dendritic cell-associated lectin 2; C-type lectin domain family 12 member A; Myeloid inhibitory C-type lectin-like receptor; DCAL-2; C-type lectin-like molecule 1; MICL; CD371; CLL-1; CLL1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein-A affinity chromatography |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q5QGZ9 Human C-type lectin domain family 12 member A |
|---|---|
| Gene Symbol | CLEC12A |
| Gene Full Name | C-type lectin domain family 12, member A |
| Background | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011] |
| Function | Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. [UniProt] |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization. [UniProt] |
| PTM | Highly N-glycosylated. Glycosylation varies between cell types. [UniProt] |
