ARG22590
anti-CLEC2 / CLEC1B antibody [17D9] (PE)
anti-CLEC2 / CLEC1B antibody [17D9] (PE) for Flow cytometry and Mouse
Overview
| Product Description | PE-conjugated Rat Monoclonal antibody [17D9] recognizes CLEC2 / CLEC1B This antibody recognizes mouse C-type lectin domain family 1 member B, also known as CLEC2 or CLEC1B. CLEC2 acts as a receptor for rhodocytin, a platelet-aggregating protein found in snake venom. CLEC2 expression is not restricted to platelets and also acts as an activation receptor on neutrophils. |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | FACS |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 17D9 |
| Isotype | IgG2b |
| Target Name | CLEC2 / CLEC1B |
| Antigen Species | Mouse |
| Immunogen | RBL-2H3 cells stably expressing HA-tagged mouse CLEC2. |
| Conjugation | PE |
| Alternate Names | CLEC2; C-type lectin domain family 1 member B; CLEC2B; PRO1384; C-type lectin-like receptor 2; CLEC-2; 1810061I13Rik; QDED721 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS, 0.09% Sodium azide, 1% BSA and 5% Sucrose. |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 1% BSA and 5% Sucrose |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9JL99 Mouse C-type lectin domain family 1 member B |
|---|---|
| Gene Symbol | Clec1b |
| Gene Full Name | C-type lectin domain family 1, member b |
| Background | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
| Calculated MW | 27 kDa |
| PTM | Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. |
Images (1) Click the Picture to Zoom In
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ARG22590 anti-CLEC2 / CLEC1B antibody [17D9] (PE) FACS image
Flow Cytometry: Mouse peripheral blood platelets stained with ARG22590 anti-CLEC2 / CLEC1B antibody [17D9] (PE).
