ARG44026
anti-CRBN antibody
anti-CRBN antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CRBN |
|---|---|
| Tested Reactivity | Hu, Rat |
| Predict Reactivity | Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CRBN |
| Antigen Species | Human |
| Immunogen | Human CRBN recombinantprotein |
| Conjugation | Un-conjugated |
| Protein Full Name | CRBN |
| Alternate Names | CRBN; Cereblon; MRT2; Protein Cereblon; MRT2A; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; Protein X 0001 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS containing 0.02% sodium azide |
| Preservative | 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CRBN |
| Gene Full Name | Cereblon |
| Background | This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. |
| Cellular Localization | Cytoplasm, Membrane, Nucleus |
| Calculated MW | 51 kDa |
| PTM | Phosphoprotein, Ubl conjugation |
Images (2) Click the Picture to Zoom In
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ARG44026 anti-CRBN antibody IHC-P image
Immunohistochemistry: Rat testis stained with ARG44026 anti-CRBN antibody at 5 μg/ml dilution.
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ARG44026 anti-CRBN antibody WB image
Western blot: Human testis stained with ARG44026 anti-CRBN antibody at 1 μg/ml dilution.
