ARG42992
anti-CRTC3 / TORC3 antibody
anti-CRTC3 / TORC3 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CRTC3 / TORC3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CRTC3 / TORC3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human CRTC3 / TORC3. |
| Conjugation | Un-conjugated |
| Alternate Names | TORC3; Transducer of regulated cAMP response element-binding protein 3; TORC-3; Transducer of CREB protein 3; CREB-regulated transcription coactivator 3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | K562 | ||||||||
| Observed Size | ~ 73 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Concentration | Batch dependent |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6UUV7 Human CREB-regulated transcription coactivator 3 Swiss-port # Q91X84 Mouse CREB-regulated transcription coactivator 3 |
|---|---|
| Gene Symbol | CRTC3 |
| Gene Full Name | CREB regulated transcription coactivator 3 |
| Background | This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. [UniProt] |
| Calculated MW | 67 kDa |
Images (1) Click the Picture to Zoom In
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ARG42992 anti-CRTC3 / TORC3 antibody WB image
Western blot: K562 cell lysate stained with ARG42992 anti-CRTC3 / TORC3 antibody at 1:1000 dilution.
