ARG11053
anti-CXCR1 antibody
anti-CXCR1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CXCR1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CXCR1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the N-terminus of Human CXCR1. (DEDYSPCMLETETLN) |
| Conjugation | Un-conjugated |
| Alternate Names | IL8RBA; C-C-CKR-1; IL-8R A; CKR-1; High affinity interleukin-8 receptor A; IL8RA; C-C; CD128; CD antigen CD181; CDw128a; CXCR-1; CXC-R1; IL-8 receptor type 1; CD181; IL8R1; CMKAR1; C-X-C chemokine receptor type 1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | ~ 40 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.025% Sodium azide and 2.5% BSA. |
| Preservative | 0.025% Sodium azide |
| Stabilizer | 2.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CXCR1 |
| Gene Full Name | chemokine (C-X-C motif) receptor 1 |
| Background | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008] |
| Function | Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. [UniProt] |
| Calculated MW | 40 kDa |
Images (2) Click the Picture to Zoom In
-
ARG11053 anti-CXCR1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG11053 anti-CXCR1 antibody.
-
ARG11053 anti-CXCR1 antibody WB image
Western blot: 1) HeLa, 2) COLO320, 3) M231 and 4) HT1080 cell lysates stained with ARG11053 anti-CXCR1 antibody.
