ARG45821
anti-CYP51A1 / CYP51 antibody
anti-CYP51A1 / CYP51 antibody for Flow cytometry,ICC/IF,Western blot and Human,Mouse,Monkey
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CYP51A1 / CYP51 |
|---|---|
| Tested Reactivity | Hu, Ms, Mk |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CYP51A1 / CYP51 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human CYP51A1 / CYP51. |
| Conjugation | Un-conjugated |
| Alternate Names | CYP51A1; Cytochrome P450 Family 51 Subfamily A Member 1; LDM; P450-14DM; P450L1; CYPL1; CYP51; CP51; Cytochrome P450, Family 51, Subfamily A, Polypeptide 1; Cytochrome P450, 51 (Lanosterol 14-Alpha-Demethylase); Lanosterol 14-Alpha Demethylase; Sterol 14-Alpha Demethylase; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; CYPLI; EC 1.14.14.154; EC 1.14.13.70 47 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 57 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CYP51A1 |
| Gene Full Name | Cytochrome P450 Family 51 Subfamily A Member 1 |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| Function | Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. [UniProt] |
| Cellular Localization | Endoplasmic reticulum; Membrane; Microsome. [UniProt] |
| Calculated MW | 57 kDa |
