ARG23191
anti-Calcitonin Receptor antibody [31/01-1H10-4-1-14]
anti-Calcitonin Receptor antibody [31/01-1H10-4-1-14] for ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rabbit
Overview
| Product Description | Mouse Monoclonal antibody [31/01-1H10-4-1-14] recognizes Calcitonin Receptor Mouse anti Human calcitonin recptor antibody, clone 31/01-1H10-4-1-14 recognizes the human calcitonin receptor, a membrane protein with seven transmembrane domains that is coupled to G protein messenger systems. Mouse anti Human calcitonin recptor antibody, clone 31/01-1H10-4-1-14 recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b human isoforms. Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and on osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis. |
|---|---|
| Tested Reactivity | Hu, Rb |
| Tested Application | ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 31/01-1H10-4-1-14 |
| Isotype | IgG2a |
| Target Name | Calcitonin Receptor |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the cytoplasmic domain of Human calcitonin receptor. (DIPIYICHQELRNEPANN) |
| Conjugation | Un-conjugated |
| Alternate Names | CT-R; CTR1; CTR; CRT; Calcitonin receptor |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Fixation with 4% paraformaldehyde is recommended for optimal results. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CALCR |
| Gene Full Name | calcitonin receptor |
| Background | This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] |
| Function | This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. [UniProt] |
| Calculated MW | 55 kDa |
