ARG52245
anti-Clavesin antibody
anti-Clavesin antibody for ICC/IF,Western blot and Rat
Cancer antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Clavesin |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Hu, Ms |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Clavesin |
| Antigen Species | Rat |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | Clavesin-1; Retinaldehyde-binding protein 1-like 1; Cellular retinaldehyde-binding protein-like; CRALBPL; RLBP1L1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | Specific for the ~ 35 kDa clavesin 1/2 protein doublet in Western blots of Rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | PBS and 50% Glycerol |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CLVS1/2 |
| Gene Full Name | clavesin 1 |
| Background | Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008). |
| Research Area | Cancer antibody; Signaling Transduction antibody |
| Calculated MW | 41 kDa |
Images (1) Click the Picture to Zoom In
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ARG52245 anti-Clavesin antibody WB image
Western Blot: rat hippocampal homogenate showing specific immunolabeling of the ~35k clavesin protein stained with Clavesin antibody (ARG52245).
