ARG54107
anti-Cytochrome P450 17A1 antibody
anti-Cytochrome P450 17A1 antibody for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes CYP17A1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Target Name | Cytochrome P450 17A1 |
| Antigen Species | Human |
| Immunogen | Purified recombinant human Cytochrome P450 17A1 protein fragments expressed in E.coli. |
| Conjugation | Un-conjugated |
| Alternate Names | CYP17; P450C17; Cytochrome P450-C17; S17AH; Cytochrome P450c17; CPT7; Steroid 17-alpha-hydroxylase/17,20 lyase; Steroid 17-alpha-monooxygenase; EC 4.1.2.30; CYPXVII; 17-alpha-hydroxyprogesterone aldolase; EC 1.14.99.9; Cytochrome P450 17A1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | 60 kDa |
Properties
| Form | Liquid |
|---|---|
| Buffer | Ascites |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P05093 Human Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|---|
| Gene Symbol | CYP17A1 |
| Gene Full Name | cytochrome P450, family 17, subfamily A, polypeptide 1 |
| Background | Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione.Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.Involved in sexual development during fetal life and at puberty. |
| Function | Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. [UniProt] |
| Cellular Localization | Membrane. |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody |
| Calculated MW | 57 kDa |
| PTM | Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity. |
Images (1) Click the Picture to Zoom In
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ARG54107 anti-Cytochrome P450 17A1 antibody WB image
Western blot: A549 cell lysate stained with ARG54107 anti-Cytochrome P450 17A1 antibody at 1:1000 dilution.
