ARG42783
anti-DEGS1 / MLD antibody
anti-DEGS1 / MLD antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DEGS1 / MLD |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DEGS1 / MLD |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human DEGS1 / MLD. |
| Conjugation | Un-conjugated |
| Alternate Names | MLD; DEGS; DES1; Des-1; FADS7; MIG15; DEGS-1; Sphingolipid delta(4)-desaturase DES1; EC 1.14.-.-; Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Membrane lipid desaturase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HeLa | ||||
| Observed Size | ~ 36 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Concentration | Batch dependent |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O15121 Human Sphingolipid delta(4)-desaturase DES1 |
|---|---|
| Gene Symbol | DEGS1 |
| Gene Full Name | delta(4)-desaturase, sphingolipid 1 |
| Background | This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010] |
| Function | Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). [UniProt] |
| Cellular Localization | Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor. [UniProt] |
| Calculated MW | 38 kDa |
| PTM | Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG42783 anti-DEGS1 / MLD antibody WB image
Western blot: HeLa cell lysate stained with ARG42783 anti-DEGS1 / MLD antibody at 1:1000 dilution.
