ARG57931
anti-DPYD antibody
anti-DPYD antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DPYD |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DPYD |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-173 of Human DPYD (NP_001153773.1). |
| Conjugation | Un-conjugated |
| Alternate Names | DHP; DPD; DHPDHASE; Dihydropyrimidine dehydrogenase [NADP(+)]; DHPDHase; DPD; EC 1.3.1.2; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | THP-1 | ||||
| Observed Size | ~ 110 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q12882 Human Dihydropyrimidine dehydrogenase [NADP(+)] Swiss-port # Q8CHR6 Mouse Dihydropyrimidine dehydrogenase [NADP(+)] |
|---|---|
| Gene Symbol | DPYD |
| Gene Full Name | dihydropyrimidine dehydrogenase |
| Background | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| Function | Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 111 kDa |
Images (1) Click the Picture to Zoom In
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ARG57931 anti-DPYD antibody WB image
Western blot: 25 µg of THP-1 cell lysate stained with ARG57931 anti-DPYD antibody at 1:1000 dilution.
