ARG45755
anti-DUBA antibody
anti-DUBA antibody for ICC/IF,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DUBA |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DUBA |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human DUBA. |
| Conjugation | Un-conjugated |
| Alternate Names | OTUD5; OTU Deubiquitinase 5; DUBA; OTU Domain-Containing Protein 5; Deubiquitinating Enzyme A; OTU Domain Containing 5; Deubiquitinase A; DKFZp761A052; Deubiquinating Enzyme A; EC 3.4.19.12; MCAND |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 75 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | OTUD5 |
| Gene Full Name | OTU Deubiquitinase 5 |
| Background | This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] |
| Function | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 61 kDa |
| PTM | Phosphoprotein. [UniProt] |
