ARG40021
anti-DYNC2H1 antibody
anti-DYNC2H1 antibody for Western blot and Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DYNC2H1 |
|---|---|
| Tested Reactivity | Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DYNC2H1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-250 of Human DYNC2H1 (NP_001073932.1). |
| Conjugation | Un-conjugated |
| Alternate Names | DNCH2; DYH1B; hDHC11; SRTD3; hdhc11; Dynein cytoplasmic heavy chain 2; SRPS2B; DHC1b; ATD3; Cytoplasmic dynein 2 heavy chain; Cytoplasmic dynein 2 heavy chain 1; Dynein heavy chain 11; DHC2; Dynein heavy chain isotype 1B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Rat testis | ||||
| Observed Size | 493 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DYNC2H1 |
| Gene Full Name | dynein, cytoplasmic 2, heavy chain 1 |
| Background | This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010] |
| Function | May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). [UniProt] |
| Cellular Localization | Cytoplasm, cytoskeleton, cilium axoneme. Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum (PubMed:8666668). [UniProt] |
| Calculated MW | 493 kDa |
Images (1) Click the Picture to Zoom In
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ARG40021 anti-DYNC2H1 antibody WB image
Western blot: 25 µg of Rat testis lysate stained with ARG40021 anti-DYNC2H1 antibody at 1:1000 dilution.
