ARG45419
anti-Duox2 antibody
anti-Duox2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Duox2 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Duox2 |
| Antigen Species | Mouse |
| Immunogen | Recombinant protein containing to mouse Duox2. |
| Conjugation | Un-conjugated |
| Alternate Names | DUOX2; Dual Oxidase 2; THOX2; LNOX2; NADH/NADPH Thyroid Oxidase P138-Tox; NADPH Oxidase/Peroxidase DUOX2; NADPH Thyroid Oxidase 2; P138-TOX; Nicotinamide Adenine Dinucleotide Phosphate Oxidase; Dual Oxidase-Like Domains 2; Flavoprotein NADPH Oxidase; P138 Thyroid Oxidase; Thyroid Oxidase 2; Large NOX 2; Long NOX 2; P138(TOX); EC 1.11.1.-; EC 1.6.3.1; NOXEF2; TDH6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 175 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | DUOX2 |
|---|---|
| Gene Full Name | Dual Oxidase 2 |
| Background | The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008] |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. [UniProt] |
| Cellular Localization | Cell junction; Cell membrane; Membrane. [UniProt] |
| Calculated MW | 175 kDa |
| PTM | Disulfide bond; Glycoprotein. [UniProt] |
