Overview

Product Description	Rabbit Polyclonal antibody recognizes Eotaxin
Tested Reactivity	Hu, Ms, Rat
Tested Application	ICC/IF, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	Eotaxin
Antigen Species	Human
Immunogen	Recombinant fusion protein corresponding to aa. 1-97 of Human Eotaxin (NP_002977.1).
Conjugation	Un-conjugated
Alternate Names	SCYA11; C-C motif chemokine 11; Eosinophil chemotactic protein; Eotaxin; Small-inducible cytokine A11

Application Instructions

Application Suggestion	Tested Application Dilution ICC/IF 1:50 - 1:100 WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size	20 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 20292 Mouse CCL11 GeneID: 29397 Rat CCL11 GeneID: 6356 Human CCL11 Swiss-port # P48298 Mouse Eotaxin Swiss-port # P51671 Human Eotaxin Swiss-port # P97545 Rat Eotaxin More
Gene Symbol	CCL11
Gene Full Name	chemokine (C-C motif) ligand 11
Background	This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
Function	In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. [UniProt]
Cellular Localization	Secreted. [UniProt]
Calculated MW	11 kDa
PTM	O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues. [UniProt]

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