ARG44772
anti-FAM175B antibody
anti-FAM175B antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes FAM175B |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | FAM175B |
| Antigen Species | Human |
| Epitope | QEYKVSSVPN TSQSYAKVIK EHGTDFFDKD GVMKDIRAIY QVYNALQEKV QAVCADVEKS ERVVESCQAE VNKLRRQITQ RKNEKEQERR LQQAVLSRQM PSESLDPAFS PRMPSSGFAA EGRSTLGDAE ASDPPPPYSD FHPNNQESTL SHSRMERSVF MPRPQAVGSS NYASTSAGLK YPGSGADLPP PQRAAGDSGE DSDDSDYENL IDPTEPSNSE YSHSKDSRPM AHPDEDPRNT |
| Conjugation | Un-conjugated |
| Alternate Names | ABRAXAS2; Abraxas 2, BRISC Complex Subunit; KIAA0157; ABRO1; FAM175B; Family With Sequence Similarity 175 Member B; BRISC Complex Subunit Abraxas 2; Abraxas Brother Protein 1; Em:AC068896.4; Family With Sequence Similarity 175, Member B; BRISC Complex Subunit Abro1; Abraxas Brother 1; Abraxas Brother; Protein FAM175B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ABRAXAS2 |
| Gene Full Name | Abraxas 2, BRISC Complex Subunit |
| Background | Enables microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in several processes, including mitotic spindle assembly; protein K63-linked deubiquitination; and response to ischemia. Located in cytoplasm. Part of BRISC complex. Colocalizes with microtubule minus-end; midbody; and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022] |
| Function | Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage. [Uniprot] |
| Cellular Localization | Cytoplasm, Cytoskeleton, Microtubule, Nucleus. [Uniprot] |
| PTM | Phosphoprotein. [Uniprot] |
Images (2) Click the Picture to Zoom In
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ARG44772 anti-FAM175B antibody IHC-P image
Immunohistochemistry: Human colon cancer stained with ARG44772 anti-FAM175B antibody at 5 µg/mL dilution.
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ARG44772 anti-FAM175B antibody IP image
Immunoprecipitation: HepG2 lysate immunoprecipitated with 2.5 µg of ARG44772 anti-FAM175B antibody.
