ARG58727
anti-FKBP3 / FKBP25 antibody
anti-FKBP3 / FKBP25 antibody for Immunoprecipitation,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes FKBP3 / FKBP25 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | FKBP3 / FKBP25 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-224 of Human FKBP3 (NP_002004.1). |
| Conjugation | Un-conjugated |
| Alternate Names | PPIase FKBP3; FK506-binding protein 3; Rotamase; FKBP25; FKBP-25; FKBP-3; EC 5.2.1.8; PPIase; 25 kDa FKBP; 25 kDa FK506-binding protein; Rapamycin-selective 25 kDa immunophilin; Peptidyl-prolyl cis-trans isomerase FKBP3; Immunophilin FKBP25 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | BT474 | ||||||
| Observed Size | 30 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q00688 Human Peptidyl-prolyl cis-trans isomerase FKBP3 |
|---|---|
| Gene Symbol | FKBP3 |
| Gene Full Name | FK506 binding protein 3, 25kDa |
| Background | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008] |
| Function | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 25 kDa |
Images (1) Click the Picture to Zoom In
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ARG58727 anti-FKBP3 / FKBP25 antibody WB image
Western blot: 25 µg of BT474 cell lysate stained with ARG58727 anti-FKBP3 / FKBP25 antibody at 1:1000 dilution.
