ARG58723
anti-FRZB antibody
anti-FRZB antibody for Western blot and Mouse,Rat
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes FRZB |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | FRZB |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 166-325 of Human FRZB (NP_001454.2). |
| Conjugation | Un-conjugated |
| Alternate Names | FRP-3; Frizzled-related protein 1; FRE; hFIZ; OS1; FrzB-1; FRZB-PEN; FRZB-1; Fritz; Secreted frizzled-related protein 3; SFRP3; FRZB1; Frezzled; FRITZ; FZRB; SRFP3; sFRP-3 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse skeletal muscle | ||||
| Observed Size | 38 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P97401 Mouse Secreted frizzled-related protein 3 |
|---|---|
| Gene Symbol | FRZB |
| Gene Full Name | frizzled-related protein |
| Background | The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010] |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 36 kDa |
Images (1) Click the Picture to Zoom In
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ARG58723 anti-FRZB antibody WB image
Western blot: 25 µg of Mouse skeletal muscle lysate stained with ARG58723 anti-FRZB antibody at 1:1000 dilution.
Specific References
WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis
ICC/IF / Mouse
