ARG45098
anti-FZD7 / Frizzled 7 antibody
anti-FZD7 / Frizzled 7 antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes FZD7 / Frizzled 7 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | FZD7 / Frizzled 7 |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide corresponding to amino acids from the N-terminal region of mouse Frizzled 7 protein |
| Conjugation | Un-conjugated |
| Alternate Names | FZD7; Frizzled Class Receptor 7; FzE3; Frizzled-7; Frizzled 7, Seven Transmembrane Spanning Receptor; Frizzled Family Receptor 7; Fz-7; HFz7; Frizzled, Drosophila, Homolog Of, 7; Frizzled (Drosophila) Homolog 7; Frizzled Homolog 7 (Drosophila); Frizzled Homolog 7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.02% NaN3 |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | FZD7 |
| Gene Full Name | Frizzled Class Receptor 7 |
| Background | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] |
| Function | May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. [Uniprot] |
| Cellular Localization | Cell membrane, Endosome, Membrane. [Uniprot] |
| Calculated MW | 64 kDa |
| PTM | Disulfide bond, Glycoprotein, Ubl conjugation. [Uniprot] |
