ARG45570
anti-GADD45B antibody
anti-GADD45B antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GADD45B |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GADD45B |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to N-terminal region of human GADD45B. |
| Conjugation | Un-conjugated |
| Alternate Names | GADD45B; Growth Arrest And DNA Damage Inducible Beta; GADD45BETA; MYD118; Growth Arrest And DNA Damage-Inducible Protein GADD45 Beta; Myeloid Differentiation Primary Response Protein MyD118; Negative Growth Regulatory Protein MyD118; DKFZP566B133; Growth Arrest And DNA-Damage-Inducible, Beta; Growth Arrest And DNA-Damage-Inducible Beta; Myeloid Differentiation Primary Response |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 18 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O75293 Human Growth arrest and DNA damage-inducible protein GADD45 beta |
|---|---|
| Gene Symbol | GADD45B |
| Gene Full Name | Growth Arrest And DNA Damage Inducible Beta |
| Background | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008] |
| Function | Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. ( GA45B_HUMAN,O75293 ). [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 18 kDa |
