ARG52307
anti-GAT1 / GABA Transporter 1 antibody
anti-GAT1 / GABA Transporter 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Rat
Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GAT1/GABA Transporter 1 |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GAT1 / GABA Transporter 1 |
| Antigen Species | Rat |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | Solute carrier family 6 member 1; GAT-1; GAT1; Sodium- and chloride-dependent GABA transporter 1; MAE; GABATHG; GABATR |
Application Instructions
| Application Suggestion |
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| Application Note | Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P23978 Rat Sodium- and chloride-dependent GABA transporter 1 |
|---|---|
| Gene Symbol | SLC6A1 |
| Gene Full Name | solute carrier family 6 (neurotransmitter transporter), member 1 |
| Background | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by highaffinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003). |
| Research Area | Neuroscience antibody |
| Calculated MW | 67 kDa |
Images (1) Click the Picture to Zoom In
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ARG52307 anti-GAT1 / GABA Transporter 1 antibody WB image
Western blot: Rat hippocampal homogenate showing specific immunolabeling of the ~67 kDa GAT1 protein stained with ARG52307 anti-GAT1 / GABA Transporter 1 antibody.
