ARG58989
anti-GCC2 / GCC185 antibody
anti-GCC2 / GCC185 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GCC2 / GCC185 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GCC2 / GCC185 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-300 of Human GCC2 (NP_852118.1). |
| Conjugation | Un-conjugated |
| Alternate Names | 185 kDa Golgi coiled-coil protein; Renal carcinoma antigen NY-REN-53; REN53; Ran-binding protein 2-like 4; RANBP2L4; GRIP and coiled-coil domain-containing protein 2; CLL-associated antigen KW-11; RanBP2L4; CTCL tumor antigen se1-1; GCC185 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HeLa | ||||||
| Observed Size | 196 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8IWJ2 Human GRIP and coiled-coil domain-containing protein 2 |
|---|---|
| Gene Symbol | GCC2 |
| Gene Full Name | GRIP and coiled-coil domain containing 2 |
| Background | The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] |
| Function | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. [UniProt] |
| Cellular Localization | Cytoplasm, Golgi apparatus, Peripheral membrane protein, trans-Golgi network membrane. [UniProt] |
| Calculated MW | 196 kDa |
Images (1) Click the Picture to Zoom In
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ARG58989 anti-GCC2 / GCC185 antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG58989 anti-GCC2 / GCC185 antibody at 1:3000 dilution.
