ARG43704
anti-GLB1 / beta Galactosidase antibody
anti-GLB1 / beta Galactosidase antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes beta Galactosidase |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GLB1 / beta Galactosidase |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to internal region of Human GLB1 / beta Galactosidase. |
| Conjugation | Un-conjugated |
| Protein Full Name | Beta-galactosidase |
| Alternate Names | ELNR1; Lactase; MPS4B; EC 3.2.1.23; Elastin receptor 1; EBP; Acid beta-galactosidase; Beta-galactosidase |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | ~ 76 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Concentration | Batch dependent |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GLB1 |
| Gene Full Name | galactosidase, beta 1 |
| Background | This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| Function | Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. [UniProt] |
| Cellular Localization | Cytoplasm; Lysosome |
| Calculated MW | 76 kDa |
| PTM | Disulfide bond; Glycoprotein; Zymogen |
Images (1) Click the Picture to Zoom In
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ARG43704 anti-GLB1 / beta Galactosidase antibody WB image
Western blot: Hela and 3T3 cells lysates stained ARG43704 anti-GLB1 / beta Galactosidase antibody at 1:1000 dilution.
