ARG10861
anti-GLB1 / beta Galactosidase antibody [DC1 4C7]
anti-GLB1 / beta Galactosidase antibody [DC1 4C7] for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and E. coli
Overview
| Product Description | Mouse Monoclonal antibody [DC1 4C7] recognizes beta Galactosidase |
|---|---|
| Tested Reactivity | E. coli |
| Tested Application | ELISA, ICC/IF, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DC1 4C7 |
| Isotype | IgG1 |
| Target Name | GLB1 / beta Galactosidase |
| Antigen Species | E. coli |
| Immunogen | Beta-galactosidase EC.3.2.1.23 from E. coli. |
| Conjugation | Un-conjugated |
| Alternate Names | ELNR1; Lactase; MPS4B; EC 3.2.1.23; Elastin receptor 1; EBP; Acid beta-galactosidase; Beta-galactosidase |
Application Instructions
| Application Suggestion |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by affinity chromatography. |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | GLB1 |
|---|---|
| Gene Full Name | galactosidase, beta 1 |
| Background | This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| Function | Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. [UniProt] |
| Calculated MW | 116 kDa |
