ARG41180
anti-GTF2IRD1 antibody
anti-GTF2IRD1 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GTF2IRD1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GTF2IRD1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 660-959 of Human GTF2IRD1 (NP_057412.1). |
| Conjugation | Un-conjugated |
| Alternate Names | WBSCR11; RBAP2; WBSCR12; BEN; WBS; Williams-Beuren syndrome chromosomal region 11 protein; Williams-Beuren syndrome chromosomal region 12 protein; GTF2I repeat domain-containing protein 1; Slow-muscle-fiber enhancer-binding protein; MUSTRD1; USE B1-binding protein; General transcription factor II-I repeat domain-containing protein 1; GTF3; CREAM1; MusTRD1/BEN; hMusTRD1alpha1; General transcription factor III; Muscle TFII-I repeat domain-containing protein 1 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | BT-474 | ||||
| Observed Size | 110 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9JI57 Mouse General transcription factor II-I repeat domain-containing protein 1 Swiss-port # Q9UHL9 Human General transcription factor II-I repeat domain-containing protein 1 |
|---|---|
| Gene Symbol | GTF2IRD1 |
| Gene Full Name | GTF2I repeat domain containing 1 |
| Background | The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] |
| Function | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 106 kDa |
Images (1) Click the Picture to Zoom In
-
ARG41180 anti-GTF2IRD1 antibody WB image
Western blot: 25 µg of BT-474 cell lysate stained with ARG41180 anti-GTF2IRD1 antibody at 1:1000 dilution.
