ARG58846
anti-HMBS antibody
anti-HMBS antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HMBS |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HMBS |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-361 of Human HMBS (NP_000181.2). |
| Conjugation | Un-conjugated |
| Alternate Names | HMBS; Hydroxymethylbilane synthase; Porphobilinogen deaminase; PORC; PBGD; EC 2.5.1.61; Pre-uroporphyrinogen synthase; PBG-D; UPS |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HeLa | ||||
| Observed Size | 45 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HMBS |
| Gene Full Name | hydroxymethylbilane synthase |
| Background | This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| Function | Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 39 kDa |
Images (1) Click the Picture to Zoom In
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ARG58846 anti-HMBS antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG58846 anti-HMBS antibody at 1:1000 dilution.
