ARG40783
anti-IL17RA antibody
anti-IL17RA antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IL17RA |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IL17RA |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 697-866 of Human IL17RA (intracellular domain) (NP_055154.3). |
| Conjugation | Un-conjugated |
| Alternate Names | Interleukin-17 receptor A; IL-17RA; IL-17 receptor A; hIL-17R; CANDF5; CDw217; IL17R; CD217; CD antigen CD217 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse lung | ||||
| Observed Size | ~ 100 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL17RA |
| Gene Full Name | interleukin 17 receptor A |
| Background | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
| Function | Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. [UniProt] |
| Cellular Localization | Membrane, Single-pass type I membrane protein, Secreted. [UniProt] |
| Calculated MW | 96 kDa |
| PTM | Glycosylated. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG40783 anti-IL17RA antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG40783 anti-IL17RA antibody at 1:1000 dilution. Blocking buffer: 3% nonfat dry milk in TBST.
