ARG40158
anti-KREMEN1 antibody
anti-KREMEN1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KREMEN1 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | IHC-P, WB |
| Specificity | Three isoforms of KREMEN1 exists as a result of alternative splicing event. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KREMEN1 |
| Antigen Species | Human |
| Immunogen | A 18 amino acid peptide within the last 50 amino acids of Human KREMEN1. |
| Conjugation | Un-conjugated |
| Alternate Names | KREMEN; KRM1; Dickkopf receptor; Kringle domain-containing transmembrane protein 1; Kremen protein 1; Kringle-containing protein marking the eye and the nose |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KREMEN1 |
| Gene Full Name | kringle containing transmembrane protein 1 |
| Background | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008] |
| Function | Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity). [UniProt] |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 52 kDa |
Images (3) Click the Picture to Zoom In
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ARG40158 anti-KREMEN1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human small intestine stained with ARG40158 anti-KREMEN1 antibody at 20 µg/ml dilution.
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ARG40158 anti-KREMEN1 antibody WB image
Western blot: Rat small intestine lysate stained with ARG40158 anti-KREMEN1 antibody at 0.125 µg/ml (left) and 0.25 µg/ml (right) dilution.
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ARG40158 anti-KREMEN1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human small intestine stained with ARG40158 anti-KREMEN1 antibody at 5 µg/ml dilution.
