ARG52399
anti-Kv3.1 phospho (Ser503) antibody
anti-Kv3.1 phospho (Ser503) antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse,Rat
Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Kv3.1 phospho (Ser503) |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Kv3.1 |
| Antigen Species | Rat |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | Potassium voltage-gated channel subfamily C member 1; EPM7; NGK2; KV3.1; KV4; Voltage-gated potassium channel subunit Kv4; Voltage-gated potassium channel subunit Kv3.1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | Specific for the ~100k Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P15388 Mouse Potassium voltage-gated channel subfamily C member 1 Swiss-port # P25122 Rat Potassium voltage-gated channel subfamily C member 1 |
|---|---|
| Gene Symbol | KCNC1 |
| Gene Full Name | potassium channel, voltage gated Shaw-related subfamily C, member 1 |
| Background | Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). |
| Research Area | Neuroscience antibody |
| Calculated MW | 58 kDa |
| PTM | N-glycosylated; contains sialylated glycans. |
Images (1) Click the Picture to Zoom In
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ARG52399 anti-Kv3.1 phospho (Ser503) antibody ICC/IF image
Immunofluorescence: medial nucleus of the trapezoid body (MNTB) cells stained with ARG52399 anti-Kv3.1 phospho (Ser503) antibody.
The left panel shows control cells.
The right panel shows cells that have been exposed to the protein kinase C activator PMA.
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