ARG45143
anti-LAR antibody
anti-LAR antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LAR |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LAR |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to internal region of human LAR. |
| Conjugation | Un-conjugated |
| Alternate Names | LAR; Leukocyte-antigen-related-like; |anti LAR antibody|LAR||Receptor-type tyrosine-protein phosphatase F|3.1.3.48|Leukocyte common antigen related|LAR|PTPRF|LAR|Leukocyte Antigen-Related Tyrosine Phosphatase|Protein Tyrosine Phosphatase Receptor Type F Polypeptide|Receptor-Linked Protein Tyrosine Phosphatase LAR|Leukocyte Antigen-Related LAR PTP Receptor|LCA-Homolog|BNAH2| |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 240 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P10586 Human Receptor-type tyrosine-protein phosphatase F |
|---|---|
| Gene Symbol | LAR |
| Gene Full Name | Leukocyte-antigen-related-like |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
| Function | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. [UniProt] |
| Cellular Localization | Membrane. [UniProt] |
| Calculated MW | 213 kDa |
| PTM | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
