ARG44246
anti-LIFR antibody [12D3] (PE)
anti-LIFR antibody [12D3] (PE) for Flow cytometry and Human
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [12D3] recognizes LIFR |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 12D3 |
| Isotype | IgG1, kappa |
| Target Name | LIFR |
| Antigen Species | Human |
| Immunogen | CD118-Fc recombinant Protein |
| Conjugation | PE |
| Alternate Names | CD118; CD antigen CD118; STWS; SJS2; LIF receptor; Leukemia inhibitory factor receptor; SWS; LIF-R |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 0.1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 4°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P42702 Human Leukemia inhibitory factor receptor |
|---|---|
| Gene Symbol | LIFR |
| Gene Full Name | leukemia inhibitory factor receptor alpha |
| Background | This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. [UniProt] |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG44246 anti-LIFR antibody [12D3] (PE) FACS image
Flow Cytometry: JAR stained with ARG44246 anti-LIFR antibody [12D3] (PE) at 10 μl / 100 μl whole blood dilution.
